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Science Leading to This Study
Frequently Asked Questions
How to Get Involved
The purpose of this clinical trial is to research the safety and effectiveness of the cannabinoid CBN (coupled with our full-spectrum Hemp Oil) for dogs with severe anxiety. Before this trial, Dr.Hempdog had already worked with this formula for 18 months with very promising results. Because of that success, we created a formal clinical trial to capture and demonstrate this evidence.
This is the first-ever clinical trial to study the anti-anxiety effects of CBN in dogs (that we know of). We are honored to have a group of accomplished veterinarians, dog trainers, and canine wellness professionals taking part in all stages of this trial.
Our first group of 10 dogs is already 90 days into the study. Each dog is receiving daily doses of our proprietary full-spectrum CBN/CBD oil (i.e. our Ultra Behavior Formula). As time goes on, we're adding more groups of dogs to the study.
Why This Research is Important:
Since we started servicing dogs with anxiety back in 2015, we noticed that our full-spectrum hemp oil was very useful for anxiety; however, there were still some dogs in some situations that it wasn't able to fully assist. This frustrated us to no end.
Because of our deep knowledge of cannabinoid science, we've known for a long time that CBN could have a positive influence on anxiety.
Over the years, we started to experiment with CBN on ourselves (like we do with most cannabinoids). After that, we started testing very small, safe doses with a few dogs we knew well that were good candidates. We learned that proper dosing is essential to have success with using this cannabinoid for anxiety, so we extensively studied CBN coupled with combinations of other cannabinoids. Based on this, we developed the most effective formula possible. Our continued experiments were incredibly successful, so we initiated a formal clinical trial to capture and further elaborate on this evidence.
Thanks to advances in the industry, we are now able to legally grow CBN from hemp for this purpose, allowing us to create this potential next-generation cannabinoid product.
Recent Updates & Preliminary Results
Latest Results & Updates:
Day 90: November 29, 2021
Next Update:Sign Up for UBF Trial Email Updates
Historical Results & Updates:
Day 60: October 30th, 2021
Day 30: September 30th, 2021
Day 14: September 14th, 2021
Day 7: September 7th, 2021
Day 1-3: August 31st, 2021
Pre-Trial Check: August 23rd, 2021
Background, Trial Purpose & the Science Leading Up to This Study
CBN is one of a very small set of cannabinoids that can agonize CB1 receptors in the brain, which is well-documented to be associated with anxiolytic, sedative, and relaxant properties (Morales 2017, Huestis 2005). Other CB1-agonizing cannabinoids include THC and the endocannabinoid Anandamide (colloquially known as the "bliss molecule"). Furthermore, studies into CBN have demonstrated that it may have anxiolytic & sedative properties when combined with other cannabinoids, namely Δ9-Tetrahydrocannabinol (THC) (Takahashi 1975). Of particular note is the fact that CBN's CB1-mediated activities are extremely similar to THC in function, yet are approximately 10 times weaker (Huestis 2005, Hartsel 2019); this means that CBN does not possess the same intoxicating, psychoactive traits as THC. Numerous veterinary safety studies further show that THC is well-tolerated in dogs and other animals when used at appropriate doses, particularly when administered concurrently with CBD and other cannabinoids (Chicoine 2020, Fernández-Trapero 2020); we reason that CBN, being pharmacologically similar to THC (yet much weaker), is therefore likely to be safe in dogs when administered at low doses.
Since we started in this industry, we had noticed that our full-spectrum hemp oil was very useful for anxiety; however, there were some dogs in some situations that our successful product wasn't able to fully assist. We've known for a long time that CBN could potentially have a positive influence on anxiety, as evidenced by several findings in humans and other animals.
The purpose of this clinical trial is to research the safety and effectiveness of the cannabinoid CBN (coupled with our full-spectrum Hemp Oil) for dogs with severe anxiety. This is especially important for animals in this study where no other medicines have fully worked, as this may indicate a novel (and potentially game-changing) therapeutic solution for this situation. Through this trial, we plan to gain a substantial amount of data that will let us see the progress of each animal from week to week and month to month. We hope that the dogs involved will see success in relieving their anxiety and will have improved quality of life; the well-being of the animals involved supercedes all else in this trial.
We're honored to have built an expansive, multi-disciplinary team of experts for this trial, including:
Professional Dog Trainers
Canine Wellness Practitioners
The Dr.Hempdog Science Team
A Variety of Dogs with Challenging Anxiety Cases
Frequently Asked Questions
We currently understand CBN to be entirely safe for dogs at the doses we use it in. Doses of CBN much higher than those found in our recommended starting level of UBF are known to act as a sleep aid; however, by giving a smaller dose, studies suggest that CBN can alleviate anxiety without causing sedation or drowsiness.
We've based all doses in this trial off of numerous relevant veterinary safety studies which show that CBN-like cannabinoids are safe and well-tolerated by dogs at the doses we use it in. If you have any additional questions, please contact us for more information.
No. Anxiety is a complex situation to deal with, and while we hope that the UBF can be an effective tool for your dog, you may wish to integrate other anxiety-relieving approaches as well. Our customers typically use the UBF daily for as long as needed, or situationally / during training or other anxiety-inducing situations, depending on their dog's unique needs.
[Would something go here about "when should I use the original vs the UBF?"
No, but you should consult a vet before changing your dog's wellness plan or volunteering them for a clinical trial.
We're currently welcoming veterinarians, canine wellness professional, dog trainers, scientists, and dogs of all ages with uncontrolled (or partially controlled) symptoms of anxiety who are under the care of a veterinary professional.
Time Commitment: At minimum, participants can expect a time commitment of 1-2 hours per week (phone/email) for the first 30 days, followed by 1-2 hours per month (phone/email) moving forwards. You'll be expected to observe your dog's behavior over the study period and participate in check-ins (phone/email). Optionally, you may be asked to submit blood work at the beginning of the trial and at the 90-day mark, which we'll cover the costs of.
If you're interested in getting involved, please let us know by clicking the button below.Request to Get Involved With This Trial